libtfbs-perl

scanning DNA sequence with a position weight matrix

Description

The TFBS perl modules comprise a set of routines to interact with the Transfac and Jaspar databases that describe a special family of proteins, the transcription factors. These bind to genomic DNA to initiate (or prevent) the readout of a gene. Once multiple binding sites are known for a transcription factor, these are gathered in a single file and are aligned in order to find position-specific characteristica that might be used to predict such binding events in novel DNA sequences.

If you use TFBS in your work, please cite "Lenhard B., Wasserman W.W. (2002) TFBS: Computational framework for transcription factor binding site analysis. Bioinformatics 18:1135-1136".

Note: the TFBS perl module is no longer under active development. All the functionality can be found in the TFBSTools Bioconductor package; users are highly encouraged to switch. <http://bioconductor.org/packages/TFBSTools/>

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Homepage

http://tfbs.genereg.net


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