profphd
secondary structure and solvent accessibility predictor
Description
This package provides prof(1), the protein secondary structure, accessibility and transmembrane helix predictor from Burkhard Rost. Prediction is either done from protein sequence alone or from an alignment - the latter should be used for optimal performance. How well does prof(1) perform? * Secondary structure is predicted at an expected average accuracy > 72% for
the three states helix, strand and loop.
* Solvent accessibility is predicted at a correlation coefficient
(correlation between experimentally observed and predicted relative
solvent accessibility) of 0.54
* Transmembrane helix prediction has an expected per-residue accuracy of
about 95%. The number of false positives, i.e., transmembrane helices
predicted in globular proteins, is about 2%.
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