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fastlink

faster version of pedigree programs of Linkage

Description

Genetic linkage analysis is a statistical technique used to map genes and find the approximate location of disease genes. There was a standard software package for genetic linkage called LINKAGE. FASTLINK is a significantly modified and improved version of the main programs of LINKAGE that runs much faster sequentially, can run in parallel, allows the user to recover gracefully from a computer crash, and provides abundant new documentation. FASTLINK has been used in over 1000 published genetic linkage studies.

This package contains the following programs:
 ilink: GEMINI optimization procedure to find a locally
           optimal value of the theta vector of recombination
           fractions
 linkmap: calculates location scores of one locus against a
           fixed map of other loci
 lodscore: compares likelihoods at locally optimal theta
 mlink: calculates lod scores and risk with two of more loci
 unknown: identify possible genotypes for unknowns

Homepage

http://www.ncbi.nlm.nih.gov/CBBResearch/Schaffer/fastlink.html


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