GNU R seroincidence calculator tool


Antibody levels measured in a cross-sectional population samples can be translated into an estimate of the frequency with which seroconversions (new infections) occur. In order to interpret the measured cross-sectional antibody levels, parameters which predict the decay of antibodies must be known. In previously published reports (Simonsen et al. 2009 and Versteegh et al. 2005), this information has been obtained from longitudinal studies on subjects who had culture-confirmed Salmonella and Campylobacter infections. A Bayesian back-calculation model was used to convert antibody measurements into an estimation of time since infection. This can be used to estimate the seroincidence in the cross-sectional sample of population. For both the longitudinal and cross-sectional measurements of antibody concentrations, the indirect ELISA was used. The models are only valid for persons over 18 years. The seroincidence estimates are suitable for monitoring the effect of control programmes when representative cross-sectional serum samples are available for analyses. These provide more accurate information on the infection pressure in humans across countries.

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