snp-sites

Description

This program finds single nucleotide polymorphism (SNP) sites from multi-fasta alignment input files (which might be compressed). Its output can be in various widely used formats (Multi Fasta Alignment, Vcf, phylip).

The software has been developed at the Wellcome Trust Sanger Institute.

A Single Nucleotide - polymorphism (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring when a Single Nucleotide — A, T, C or G — in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes. For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case there are two alleles. Almost all common SNPs have only two alleles.

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Homepage

https://github.com/sanger-pathogens/snp-sites

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Install snp-sites